Ex-Novartis CMO John Tsai joins Daiichi Sankyo
John Tsai is currently CEO of UK biotech Forcefield Therapeutics and a partner at investment group Syncona.
Daiichi Sankyo has named John Tsai as its new chief medical officer (CMO), replacing Ken Takeshita, who is stepping down after five years in the role on 1st April.
Tsai's appointment comes three years after he left the CMO role at Novartis as part of a sweeping reorganisation that resulted in the merger of its pharma and oncology businesses into an 'innovative medicines division and led eventually to the spinout of the group's generics unit Sandoz.
Since then, Tsai has been working as chief executive of UK biotech Forcefield Therapeutics and as a partner for investment group Syncona, whilst holding board roles at Purespring Therapeutics and Blueprint Medicines.
Daiichi Sankyo's chief executive, Hiroyuki Okuzawa, said Tsai will be a "formidable addition" to the company's leadership team as it executes a new five-year business plan at the end of the current financial year.
At Novartis, Tsai is credited with the development of 160 new projects and 500 clinical trials, leading to regulatory approvals for 15 new medicines, including breakthrough products like spinal muscular atrophy (SMA) gene therapy Zolgensma (onasemnogene abeparvovec) and radioligand therapy Pluvicto (lutetium Lu 177 vipivotide tetraxetan) for prostate cancer.
"Joining Daiichi Sankyo at such a pivotal time is both an honour and exciting opportunity," said Tsai. "Daiichi Sankyo has built a world-class scientific organisation, and I look forward to building on this legacy to further drive innovation for patients."
Daiichi Sankyo also thanked Takeshita for his service, saying that he had led the transformation of Daiichi Sankyo's R&D organisation "into a globally integrated engine of innovation," and helped to solidify the company's position in the oncology sector.
The company added that Takeshita "accelerated and expanded" the Japanese group's antibody-drug conjugate (ADCs) portfolio – which includes AstraZeneca-partnered Enhertu (trastuzumab deruxtecan) and Datroway (dapotamab deruxtecan) – already on the market – and numerous clinical-stage candidates, including three ADCs partnered with MSD in a $22 billion pact signed in 2023.
Enhertu in particular has been the key driver of Daiichi Sankyo's strong revenue growth over the last five years and achieved sales of nearly $5 billion last year, with GlobalData predicting it could reach more than $14 billion by 2031.
There has been one recent setback in Daiichi Sankyo's ADC programme, however; namely, the decision was taken to withdraw a marketing application for MSD-partnered anti-HER3 candidate patritumab deruxtecan, a few months after it was knocked back by the FDA.
