Looking back, looking forward – Janssen’s 60 years on the psychiatry horizon

Since Dr Paul Janssen established his company in 1953, to research mental health conditions, it has launched 16 neuroscience treatments in the UK. Today, the focus is on predicting and pre-empting, improving targeted treatments and partnering on initiatives to reduce stigma and support patients.

Mental illness is the single largest cause of disability in the UK.1 Mental health issues, such as anxiety and depression, are estimated to affect approximately one in six people at any time in the UK.2

Mental and physical health are closely linked, with people with severe and prolonged mental illness at risk of dying around 15-20 years earlier than the general population.3 However, only around one quarter of those with mental health conditions are receiving treatment, and only 13% of the NHS budget goes towards such treatments.1

As well as the medical burden, the economic and social burden is considerable:

  • The cost of mental health problems to the economy is estimated at £105 billion/year – roughly the cost of the entire NHS3
  • Mental health problems account for over twice the number of Employment and Support Allowance and Incapacity Benefit claims, compared with musculoskeletal conditions1· The employment rate of people with severe and enduring mental health problems is 7%1
  • The predicted cost of mental illnesses to society is higher than that for cancer, diabetes and chronic respiratory diseases combined4
Psychiatry landscape in the 1950s

Historically, people with mental health problems have been stigmatised and marginalised. It required the Mental Health Act of 1959 to give the mentally ill the same legal status and protection as the physically ill.5

Mental health services have been underfunded, poorly staffed and have not had the same priority as that awarded to physical health. Mental health patients were put into out-dated buildings, away from the general population, with fragmented services and care. Patients often faced long-term or life-long institutionalisation.

Prior to the development of novel drugs, treatments were largely non-pharmacological and, given the long-term and intransigent nature of symptoms, were often highly experimental, such as lobotomy and insulin shock treatment.

However, this period saw a very gradual transition from the reliance on psychoanalytical treatments to the psychopharmacological era, which supported the assertion that psychiatric disorders had underlying biological disturbances that could be targeted.

Janssen’s story

Janssen was founded in 1953 by Dr Paul Janssen, who aimed to change many of these issues through his extensive research. As he said, “There is so much more to be done; the patients are waiting.”

Dr Janssen’s research culminated in the breakthrough discovery of one of the earliest antipsychotic treatments in 1958 (the first antipsychotic was chlorpromazine, which was discovered in 1950). Since then, Janssen has continued to identify novel treatments for schizophrenia and psychosis with improved side effect profiles compared to typical or first-generation treatments.6 Also, innovations in long-acting treatments have assisted adherence and reduced the risk of relapse.7

In fact, Janssen has launched 16 neuroscience treatments in the UK, to treat a range of conditions. Importantly, the discovery of novel medicines has allowed the development of more holistic patient treatment approaches, including training and psychological therapies, since the most florid symptoms are better controlled.

Ongoing evolution in psychiatry

Mental health treatment has been transformed over the last 60 years, aided by medical breakthroughs, partnerships, and technological advances in brain imaging, drug discovery, genetics and genomics.

Significant advances in the understanding and treatment of psychiatric diseases have been accompanied by a growing commitment in communities, workplaces, schools and government to change perceptions. Mental health conditions are now being pushed to the top of the health care agenda, with continued investment, and awareness and education campaigns, such as the recent “We Swear” campaign by the mental health charity, MQ: Transforming Mental Health through Research.

The new emphasis on mental health was demonstrated by documents such as the 2016 ‘Five Year Forward View for Mental Health’3 and the Medical Research Council’s 2017 ‘Strategy for Lifelong Mental Health Research’.2

There is now increasing use of digital and mobile health approaches to improve access to psychological/cognitive behavioural therapies, as well as investment from stakeholders in the Innovative

Medicines Initiative 2 (IMI 2) programme to identify digital approaches to proactively assist relapse prediction.

Ongoing R&D

Our ongoing research is focused on improving understanding of the basic biology and neuropathology of the different diseases, and discovering novel targets towards the identified biology, just as with other conditions, such as heart disease and cancer. Also, we are working to address specific patient needs, such as increasing speed of effect and targeting poorly-treated symptoms.

For example:

  • Janssen is working with Minerva Neurosciences on research for sleep disturbances in major depressive disorder (MDD)
  • A number of earlier phase programmes are evaluating targeting of novel areas, such as neuroimmune cascades, cellular resilience and dysfunctional brain circuits.
Partnerships and education

Improving the lives of people with mental health conditions is best achieved by understanding the reality of the patient experience, so we actively invest in building trusted partnerships, including in mental health policy. For example:

  • Sponsoring students from the developing world to tackle the stigma of mental health issues in countries in the NGO sector
  • Working with the government to highlight the severity, potential impact and cost implications of not working to tackle these conditions
  • Supporting work with the Employment Task & Finish Group and numerous mental health charities
  • Investing in the UK government-initiated Dementia Discovery Fund and the Dementias Platform UK, as well as public-private partnerships such as the Wellcome Trust Neuroimmunology in Mood and Alzheimer’s Consortium
  • Helping to reduce the stigma associated with mental illness through patient support campaigns, such as ‘Schizophrenia24x7’, sponsorship of the Dr Guislain Award for ‘Breaking the chains of stigma’, and the Janssen Healthy Minds programme
  • Partnering with Rethink Mental Illness on developing tools for patients, carers and healthcare professionals to support discussions around informed treatment choices
  • Collaborating with SANE in 2015 on assessing the “preventing crisis through goal lead support packages” project, which focuses on individuals with serious mental illness, facing negative and self-destroying thoughts and feelings.
Looking to the future

We have always been, and remain, committed to psychiatry. Our researchers continue to identify novel targets based on a growing understanding of the biology. We are continuing to improve existing treatments, in terms of speed of effect, side effect profile, duration of action, as well as exploring early intervention, identifying responders to treatment and targeting treatment-resistant disease.

Today, focus is on a dimensional approach to central nervous system disorders that recognises inter-patient variability. The goal is to offer personalised treatments, which improve patient choice and, hopefully, outcomes. Also, to move from ‘diagnose and treat’ to ‘predict and pre-empt’, avoiding irreversible cellular and physiological damage.

About the author:

Declan Jones is VP, Neuroscience Lead at the Johnson & Johnson (J&J) Innovation Centre in London. J&J bought Janssen in 1961. For more information visit www.janssen.co.uk.

Read more:

J&J showcases its 10 blockbuster prospects

References

1 NHS: Five Year Forward View, 2014. Available from: https://www.england.nhs.uk/wp-content/uploads/2014/10/5yfv-web.pdf. Last accessed: June 2017.
2 Medical Research Council. Strategy for Lifelong Mental Health Research, April 2017. Available from: https://www.mrc.ac.uk/documents/pdf/strategy-for-lifelong-mental-health-research/. Last accessed: June 2017.
3 NHS: The Five Year Forward View For Mental Health, 2016. Available from: https://www.england.nhs.uk/wp-content/uploads/2016/02/Mental-Health-Taskforce-FYFV-final.pdf. Last accessed: June 2017.
4 Bloom D E, et al. The Global Economic Burden of Noncommunicable Diseases. Geneva: World Economic Forum, 2011.
5 Lipsedge M, et al. Psychiatry 50 years ago. British Journal of Hospital Medicine. 2016;77(10):569-571.
6 Rethink Mental Illness, 2017. Antipsychotics Factsheet. Available from: https://www.rethink.org/resources/a/antipsychotics-factsheet. Last accessed: June 2017.
7 Brissos S, et al. The role of long-acting injectable antipsychotics in schizophrenia: a critical appraisal. Therapeutic Advances in Psychopharmacology. 2014;4(5):198-219.